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. 2019 Feb 13;9:1912. doi: 10.1038/s41598-018-36802-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A single FRONSAC waveform improves many scan prescriptions. While routine changes in scan prescription (orientation, field of view, or resolution) alter the linear gradients, FRONSAC gradients provide marked improvements in experimental images without requiring alteration. This means that the required field mapping can be performed for a single waveform that can then be used to improve a wide range of scans, which is a critical feature for clinical application. Note R = 6 in this figure is an approximation signifying 12/64, 23/128, and 45/256 measurement lines. Black space in the images has been cropped for better visualization.