Table 3.
Copy number amplification regions in HCB-514 cell line.
| Chromosome Region | CNV | Cytoband | Cancer genes |
|---|---|---|---|
| chr1 | Amplification | p36.33; q32.1 | |
| chr1 | High amplification | q32.1 - q43 | H3F3A, FH |
| chr1 | Amplification | q43 - q44 | AKT3 |
| chr2 | High amplification | p25.3 - p22.3 | MYCN, C2orf44, NCOA1, DNMT3A, ALK |
| chr2 | High amplification | p22.3 - p21 | EML4 |
| chr2 | Amplification | p21 - q33.1 | MSH2, MSH6, FBXO11, BCL11A, REL, XPO1, IGL@, TTL, PAX8, ERCC3, CHN1, HOXD13, HOXD11, NFE2L2, PMS1, SF3B1 |
| chr2 | Amplification | q37.3 | |
| chr3 | High amplification | q11.1 - q26.1 | TFG, CBLB, GATA2, RPN1, FOXL2, WWTR1, GMPS, MLF1 |
| chr3 | High amplification | q26.1 - q29 | EVI1, PIK3CA, SOX2, ETV5, EIF4A2, BCL6, LPP, DCUN1D1, PRKCI |
| chr3 | High amplification | q29 | TFRC |
| chr5 | Amplification | p15.33 - p11 | IL7R, LIFR, SKP2, TERT |
| chr6 | Amplification | q12 | |
| chr7 | Amplification | p22.3 - q11.21 | CARD11, PMS2, ETV1, HNRNPA2B1, HOXA9, HOXA11, HOXA13, JAZF1, IKZF1, EGFR |
| chr8 | Amplification | p23.3 - q24.3 | PCM1, WRN, WHSC1L1, FGFR1, HOOK3, TCEA1, PLAG1, CHCHD7, NCOA2, HEY1, COX6C, EXT1, MYC, NDRG1, RECQL4, C8orf33, C8orf4 |
| chr9 | Amplification | q32 | |
| chr11 | Amplification | q12.3 - q13.4 | MEN1, CCND1, ORAOV1, FADD |
| chr11 | Amplification | q13.4 - q22.1 | NUMA1, PICALM, MAML2, GAB2, YAP1 |
| chr11 | High amplification | q22.1 - q22.3 | BIRC2, BIRC3 |
| chr12 | Amplification | p13.33 | |
| chr12 | Amplification | q23.1 - q24.33 | ALDH2, PTPN11, BCL7A |
| chr14 | Amplification | q11.1 - q32.33 | BCL2L2, CCNB1IP1, TRA@, NKX2-1, NIN, KTN1, GPHN, TSHR, TRIP11, GOLGA5, DICER1, TCL6, TCL1A, BCL11B, AKT1, IGH@ |
| chr15 | Amplification | q21.3 - q26.3 | IGF1R, FLJ27352, TCF12, PML, NTRK3, IDH2, CRTC3, BLM |
| chr16 | Amplification | p13.3 | |
| chr16 | High amplification | p13.3 - p11.2 | TSC2, CREBBP, CIITA, SOCS1, TNFRSF17, ERCC4, MYH11, PALB2, IL21R, FUS |
| chr17 | Amplification | p13.3 - q11.2 | MAPK7, YWHAE, USP6, TP53, PER1, GAS7, MAP2K4, NF1, SUZ12 |
| chr18 | High amplification | p11.31 | |
| chr18 | Amplification | p11.31 - p11.23 | |
| chr18 | Amplification | p11.1 - q23 | DCC, ZNF521, SS18, MALT1, BCL2 |
| chr19 | Amplification | p13.2 | |
| chr20 | Amplification | p13 - q13.33 | BCL2L1, NCOA3, AURKA, ZNF217, EEF1A2, ASXL1, MAFB, TOP1, SDC4, GNAS, SS18L1 |