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. 2019 Feb 13;9:1984. doi: 10.1038/s41598-018-36254-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic organization and functional comparison of the hpa operon in B. cytotoxicus strains. Putative functions are as follows: lysR – regulator of the operon; hpaI - 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; hpaE - 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; hpaD - 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Cyt-T – cytidyltransferase; acetate transporter - cation acetate symporter; hpaG - 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; hpaF - 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; tetratricop. Prot - tetratricopeptide repeat protein. The 330-bp hypothetical gene between Cyt-T and the acetate transporter is not shown.