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. 2019 Feb 13;10:733. doi: 10.1038/s41467-019-08554-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Ubiquitous HAMP mRNA expression across cancers. a The heatmap shows the mRNA expression levels of HAMPs across cancers. The intensity of purple indicates the percentile (25th, 50th, 75th, and 90th) of the FPKM value of each HAMP in a given cancer type. The phylogenetic trees were generated by multiple sequence alignments of the full-length sequences of the proteins. b Summary of the overall mRNA expression of each HAMP across 33 cancer types. The intensity of purple indicates the number of cancer types in which a given HAMP was defined as detectable (the 90th FPKM value ≥ 1). Gray indicates the HAMPs with mRNA expression levels that are cancer type-specific. The phylogenetic trees were generated by multiple sequence alignments of the full-length sequences of the proteins. c TCGA specimens were arranged in two dimensions based on the similarity of their HAMP expression profiles by the dimensionality reduction analysis t-SNE (t-distributed stochastic neighbor embedding). Colors represent cancer types. The cancer types (n = 33) and their color keys are listed based on tissue origin