Table 2.
COG entries involved in Restriction-Modification systems (V), Polyketide biosynthesis (Q), and Eukaryotic-like protein repeats (R) across the genomes of sponge-associated Alphaproteobacteria analyzed in this study.
| COG | And.1 | Ery.2 | Lab.3 | Lok.4 | Pse.5 | R.46 | R.307 | Rue.8 | Sph.9 | Tat.10 | Class | Description |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| COG0286 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 2 | V | Type I restriction-modification system methyltransferase subunit |
| COG0732 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | V | Restriction endonuclease S subunits |
| COG1002 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | V | Type II restriction enzyme, methylase subunits |
| COG1403 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | V | Restriction endonuclease |
| COG3440 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | V | Predicted restriction endonuclease |
| COG4096 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | V | Type I site-specific restriction-modification system, R (restriction) subunit and related helicases |
| COG3183 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | V | Predicted restriction endonuclease |
| COG3440 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | V | Predicted restriction endonuclease |
| COG3587 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | V | Restriction endonuclease |
| COG1002 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | V | Type II restriction enzyme, methylase subunits |
| COG1401 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | V | GTPase subunit of restriction endonuclease |
| COG3587 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | V | Restriction endonuclease |
| COG2761 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | Q | Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis |
| COG3315 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | Q | O-Methyltransferase involved in polyketide biosynthesis |
| COG3319 | 0 | 0 | 1 | 1 | 2 | 0 | 2 | 1 | 0 | 1 | Q | Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases |
| COG3321 | 0 | 0 | 3 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | Q | Polyketide synthase modules and related proteins |
| COG5285 | 5 | 1 | 3 | 3 | 4 | 4 | 3 | 4 | 3 | 5 | Q | Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin |
| COG0666 | 3 | 1 | 1 | 1 | 2 | 0 | 0 | 1 | 1 | 0 | R | Ankyrin repeats |
| COG0457 | 12 | 6 | 9 | 2 | 5 | 2 | 2 | 8 | 6 | 2 | R | Tetratricopeptide repeats |
| COG2319 | 2 | 0 | 5 | 1 | 1 | 2 | 4 | 1 | 0 | 1 | R | WD40 repeats |
| COG1520 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | R | WD40 repeats |
| COG4886 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | R | Leucine-rich repeat (LRR) protein |
| COG5424 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | R | pyrrolo-quinoline quinone repeat (PQQ) |
| COG0790 | 8 | 2 | 13 | 1 | 6 | 4 | 1 | 1 | 3 | 3 | R | Tetratricopeptide repeats |
COG Class V - “Defense mechanisms”; COG Class Q - “Secondary metabolites biosynthesis, transport and catabolism”; COG Class R - “General function prediction only” (1) Anderseniella sp. Alg231-50, (2) Erythrobacter sp. Alg231-14, (3) Labrenzia sp. Alg231-36, (4) Loktanella sp. Alg231-35, (5) Pseudovibrio sp. Alg231-02, (6) Rhodobacteraceae bacterium Alg231-04, (7) Rhodobacteraceae bacterium Alg231-30, (8) Ruegeria sp. Alg231-54, (9) Sphingorhabdus sp. Alg231-15, (10) Tateyamaria sp. Alg231-49.