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. 2019 Feb 13;9:1924. doi: 10.1038/s41598-018-36066-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier curves for the primary outcome measure according to the severity of anemia. (A) Entire cohort. (B) Conservative stratum. (C) Initial AVR stratum. The primary outcome measure was defined as a composite of aortic valve-related death of heart failure hospitalization. Severity of anemia was classified as no anemia (Hb ≥ 13.0 g/dl for men, and≥12.0 g/dl for women), mild anemia (Hb 11.0–12.9 g/dl for men, and 11.0–11.9 g/dl for women), and moderate/severe anemia (Hb ≤ 10.9 g/dl). AVR = aortic valve replacement, and Hb = hemoglobin.