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. 2019 Feb 13;9:1974. doi: 10.1038/s41598-019-39122-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EZH2 expression increases with increasing tumor grade and is upregulated in breast cancer cell lines. (A) [i] Immunohistochemistry performed in tissue array of different grades of invasive breast tumors show EZH2 expression. Insets show 10 times digitally magnified pictures of images captured with 40X objective. [ii] The scatter plot shows the percent EZH2 positive cancer cells present in different grades of tumor tissues. [iii] Graph displays EZH2 expression in different grades of tumor in comparison to normal breast tissues as observed in MERAV expression database. (B) [i] Western blot displays EZH2 protein expression in breast cancer cell lines along with normal breast epithelial MCF10A cells. [ii] Graph shows normalized expression of EZH2 protein using ImageJ software. [iii] EZH2 expression in ER (+)ve and ER (−)ve breast cancer cells along with non-cancerous breast cells as observed in MERAV expression database is presented in the graph. One way ANOVA was used for statistical analysis. *P < 0.05, ***P < 0.001. Scale bar 200 µm (4X) and 50 µm (40X).