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. 2019 Feb;58(2):267–276.e8. doi: 10.1016/j.jaac.2018.06.037

Table 2.

Linear Regression Models Showing Tobacco Use as a Predictor of Psychotic Experiences

Unadjusted Model
Adjusted Model
Unadjusted Model
Adjusted Model
R2 β 95% CI R2 β 95% CI R2 β 95% CI R2 β 95% CI
Paranoia .017 .160 Grandiosity .003 .046
Tobacco use Tobacco use
 Occasional smokers 0.27 0.17–0.37 0.13 0.02–0.23  Occasional smokers 0.05 –0.05–0.15 0.05 –0.07–0.17
 Regular smokers 0.46 0.31–0.60 0.17 0.00–0.34  Regular smokers 0.22 0.07–0.37 0.17 –0.01–0.35
Sex –0.04 –0.11–0.02 Sex 0.26 0.19–0.33
Age –0.08 –0.13 to –0.03 Age –0.02 –0.08–0.03
Ethnicity –0.07 –0.21–0.07 Ethnicity 0.36 0.21–0.51
Cannabis use 0.10 –0.04–0.24 Cannabis use –0.04 –0.19–0.12
Sleep disturbance 0.34 0.31–0.38 Sleep disturbance –0.02 –0.05–0.02
Significant life events 0.10 0.07–0.14 Significant life events 0.15 0.12–0.19
Socio-economic status 0.08 0.05–0.12 Socio-economic status 0.01 –0.02–0.05
Prenatal maternal smoking 0.01 –0.10–0.11 Prenatal maternal smoking 0.00 –0.12–0.11
Hallucinations 0.014 .145 Anhedonia .004 .083
Tobacco use Tobacco use
 Occasional smokers 0.19 0.09–0.29 0.07 –0.04–0.18  Occasional smokers –0.14 –0.24 to –0.04 –0.12 –0.23 to –0.01
 Regular smokers 0.48 0.33–0.62 0.24 0.06–0.41  Regular smokers 0.17 0.03–0.32 0.16 –0.020.34
Sex 0.10 –0.16 to0.03 Sex 0.49 0.42–0.56
Age 0.09 –0.14 to –0.04 Age –0.01 –0.06–0.04
Ethnicity 0.11 –0.03–0.26 Ethnicity 0.00 –0.15–0.15
Cannabis use 0.11 –0.04–0.25 Cannabis use 0.01 –0.14–0.16
Sleep disturbance 0.32 0.28–0.35 Sleep disturbance 0.14 0.11–0.18
Significant life events 0.12 0.08–0.15 Significant life events –0.11 –0.15 to –0.07
Socio-economic status –0.03 –0.07–0.00 Socio-economic status 0.02 –0.02–0.06
Prenatal maternal smoking –0.03 –0.14–0.07 Prenatal maternal smoking 0.01 –0.11–0.12
Cognitive disorganization 0.025 0.226 Negative symptomsa .011 .052
Tobacco use Tobacco use
 Occasional smokers 0.20 0.10–0.30 0.09 –0.02–0.19  Occasional smokers –0.06 –0.16–0.04 –0.06 –0.18–0.05
 Regular smokers 0.68 0.54–0.83 0.34 0.17–0.50  Regular smokers 0.45 0.30–0.59 0.23 0.04–0.41
Sex –0.30 –0.37 to –0.24 Sex 0.19 0.12–0.26
Age –0.05 –10 to –0.00 Age –0.10 –0.15 to –0.04
Ethnicity 0.02 –0.11–0.16 Ethnicity 0.06 –0.09–0.21
Cannabis use 0.06 –0.08–0.20 Cannabis use 0.05 –0.10–0.21
Sleep disturbance 0.40 0.36–0.43 Sleep disturbance 0.14 0.10–0.18
Significant life events 0.06 0.02–0.09 Significant life events –0.02 –0.06–0.02
Socio-economic status –0.08 –0.11 to –0.04 Socio-economic status –0.13 –0.17 to –0.09
Prenatal maternal smoking 0.03 –0.08–0.13 Prenatal maternal smoking 0.13 0.01–0.24

Note: Significance at p < .05 is shown in boldface type. Adjusted R2 reported for adjusted models. Reference groups: for tobacco use, non-smokers; sex, female; for ethnicity, white; for cannabis use, no; for prenatal maternal smoking, no. Unadjusted model results: paranoia (F2,3600 = 30.33, p < .001), hallucinations (F2,3604 = 25.61, p < .001), cognitive disorganization (F2,3603 = 46.86, p < .001), grandiosity (F2,3602 = 4.52, p = .011), anhedonia (F2,3601 = 6.86, p = .001) and parent-rated negative symptoms (F2,3580 = 19.49, p < .001). Adjusted model results: paranoia (F10,2985 = 57.88, p < .001), hallucinations (F10,2989 = 51.86, p < .001), cognitive disorganization (F10,2989 = 88.65, p < .001), grandiosity (F10,2989 = 15.56, p < .001), anhedonia (F10,2986 = 28.02, p < .001), and parent-rated negative symptoms (F10,2970 = 17.30, p < .001).

a

Parent-rated.