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. 2019 Feb 1;7:62–66. doi: 10.1016/j.pvr.2019.01.003

Fig. 2.

Fig. 2

Accumulated high-grade anal squamous neoplasias (HSIL) according to the total number of high resolution anoscopies (HRA) with subsequent biopsy (black line) and the prevalence of high-risk human papillomavirus (HR-HPV) (grey line) in 581 HIV-infected men who have sex with men seen between 2010 and 2017 in an HIV outpatient clinic of a tertiary care centre in Seville, Spain. Event #1: One single expert pathologist responsible for biopsy interpretation; Event #2: Observer participates at additional one week expert training. The slope of the HR-HPV curve from the hundredth HRA onwards was −0.0003 (r2 = 0.97).