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. 2019 Feb 13;9:1970. doi: 10.1038/s41598-019-38512-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic tree of Sema domain containing proteins. Unrooted representation of a phylogenetic hypothesis inferred by a Bayesian method with the aid of the software MrBayes 3.2.6 implemented on CIPRES⁶³ based on alignment of all Sema plus PSI domain sequences of all proteins described in this study. The “1.0” label in the center is the posterior probability at this branch point calculated by MrBayes. Red lines indicate semaphorins, blue lines plexins, green lines Met RTKs, and orange lines Met-LP RTKs. The plexins and semaphorins of choanoflagellates branch off from the base of the respective plexin and semaphorin clades. Human plexin classes (Plexin-A and Plexin-B/C/D) and bilaterian semaphorin classes (Sema1–7) are indicated to provide reference to the detailed tree representations shown in Figs 6 and 7. Scale bar represents peptide sequence divergence of the sequences.