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. 2019 Feb 13;9:1970. doi: 10.1038/s41598-019-38512-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model of evolutionary origin of Met and Met-LP RTKs. Protein models below taxon brackets indicate presence of Met-LPs and/or Mets in the respective clade. Phylogenetic data suggests a scenario in which an ancestral Met RTK might have evolved in a common ancestor of Bilateria. Met-LPs might have formed twice independently by similar tyrosine kinase domain acquisition events in lineages leading to Lophotrochozoa and Echinodermata (indicated by green plus signs). Loss of Met RTKs would have occurred in the lineage leading to Ecdysozoa (indicated by red minus signs). Protein domains: see legends of Figs 1, 3, and 4. Photo/image credits: C. teleta: François Michonneau (https://francoismichonneau.net/photos/capitella-telata) © 2018 by François Michonneau (CC-BY 4.0); A. californica: Genevieve Anderson; C. elegans: Bob Goldstein; S. maritima: Carlo Brena; D. melanogaster: Hans Smid; A. planci: Denis Zorzin; B. belcheri: Arthur Anker; H. sapiens: NASA.