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. 2019 Feb 13;4(1):e00647-18. doi: 10.1128/mSphere.00647-18

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Copyright © 2019 Osowicki et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — In vitro characterization of contemporary candidate strains for human challenge. (A) Growth kinetics of candidate strains in RPMI 1640 supplemented with 2% Veggietone (filled symbols) and Todd-Hewitt broth with 1% yeast extract (open symbols). Means and standard deviations (SD) are representative of three separate experiments done in triplicate. (B) Strain attachment and cellular invasion. Means and SD are from three separate experiments with triplicate wells. (C) Capsular hyaluronic acid quantification. Means and SD are derived from a single experiment. (D) Resistance of M75, M12, and 5448 to killing by human neutrophils. Means and SD are from three separate experiments using different blood donors, with seven biological replicates. (E) Strain lethality in a humanized plasminogen transgenic AlbPLG1 murine invasive disease model (n = 10 for each strain).