TABLE 3.
Group A Streptococcus virulence factor genomic screen
| Gene | Function | M75 611024 | M12 611025 | M1T1 5448 | CDC SS-496 |
|---|---|---|---|---|---|
| cfa-cfb | CAMP factor | ✓ | ✓ | ✓ | ✓ |
| tee (cpa) | T-pilus antigen | ✓ | ✓ | ✓ | |
| cppA | Putative C3-degrading proteinase | ✓ | ✓ | ✓ | ✓ |
| emm | M-protein | ✓ | ✓ | ✓ | ✓ |
| endoS | Endo-beta-N-acetylglucosaminidase F2 precursor | ✓ | ✓ | ✓ | ✓ |
| fbp54 | Fibrinogen-binding protein | ✓ | ✓ | ✓ | ✓ |
| fctA | Major pilin Ap1 (FctA) | ✓ | ✓ | ||
| fctB | Minor pilin Ap2 (FctB) | ✓ | ✓ | ||
| grab | Protein G-related alpha 2M-binding protein | ✓ | ✓ | ✓ | |
| hasA | HA synthase capsule | ✓ | ✓ | ✓ | ✓ |
| hasB | UDP-glucose 6-dehydrogenase capsule | ✓ | ✓ | ✓ | ✓ |
| hasC | Putative UDP-glucose pyrophosphorylase | ✓ | ✓ | ✓ | ✓ |
| htrA-degP | Serine protease | ✓ | ✓ | ✓ | ✓ |
| htsA | Putative ABC transporter periplasmic binding protein | ✓ | ✓ | ✓ | ✓ |
| htsB | Putative ABC transporter permease | ✓ | ✓ | ✓ | ✓ |
| htsC | Putative ABC transporter ATP-binding protein | ✓ | ✓ | ✓ | ✓ |
| hyl | Hyaluronoglucosaminidase | ✓ | ✓ | ✓ | ✓ |
| hylA | HA lyase precursor | ✓ | ✓ | ✓ | |
| hylP | Hyaluronoglucosaminidase | ✓ | ✓ | ✓ | ✓ |
| ideS-mac | IgG-degrading protease | ✓ | ✓ | ✓ | ✓ |
| lepA | Signal peptidase I | ✓ | ✓ | ||
| lmb | Laminin binding protein | ✓ | ✓ | ✓ | ✓ |
| mf-spd | Deoxyribonuclease | ✓ | ✓ | ✓ | ✓ |
| mf3 | Deoxyribonuclease | ✓ | ✓ | ✓ | |
| plr-gapA | Glyceraldehyde-3-phosphate dehydrogenase | ✓ | ✓ | ✓ | ✓ |
| prtF2 | Collagen adhesion protein | ✓ | |||
| psaA | Manganese-binding protein | ✓ | ✓ | ✓ | ✓ |
| sagA | Streptolysin S precursor | ✓ | ✓ | ✓ | ✓ |
| sclA | Collagen-like surface protein A | ✓ | ✓ | ✓ | ✓ |
| sclB | Putative collagen-like protein | ✓ | ✓ | ||
| scpA | C5A peptidase precursor | ✓ | ✓ | ✓ | ✓ |
| sda | Phage-encoded streptodornase Sda | ✓ | ✓ | ||
| sdn | Phage-encoded endonuclease Sdn | ✓ | |||
| sfbII-sof | Fibronectin-binding protein | ✓ | ✓ | ||
| sfbX | Fibronectin-binding protein | ✓ | ✓ | ||
| shp | Hypothetical protein | ✓ | ✓ | ✓ | ✓ |
| shr | Fe3+-siderophore transporter | ✓ | ✓ | ✓ | ✓ |
| sic | Streptococcal inhibitor of complement | ✓ | |||
| ska | Streptokinase precursor | ✓ | ✓ | ✓ | ✓ |
| slo | Streptolysin O | ✓ | ✓ | ✓ | ✓ |
| smeZ | Enterotoxin | ✓ | ✓ | ✓ | ✓ |
| speB | Cysteine protease | ✓ | ✓ | ✓ | ✓ |
| speA | Exotoxin A | ✓ | |||
| speG | Exotoxin G | ✓ | ✓ | ✓ | ✓ |
| speH | Exotoxin H | ✓ | ✓ | ||
| speI | Exotoxin I | ✓ | ✓ | ||
| speJ | Exotoxin J | ✓ | ✓ | ||
| speL | Exotoxin L | ✓ | |||
| speM | Exotoxin M | ✓ | |||
| spyA | C3 family ADP-ribosyltransferase | ✓ | ✓ | ✓ | ✓ |
| srtC1 | Sortase | ✓ | ✓ | ||
| ssa | Streptococcal superantigen A | ✓ | |||
| tig-ropA | Trigger factor | ✓ | ✓ | ✓ | ✓ |