TABLE 4.
Gene/antigen | Gene identifiera | Function | M75 611024 | M12 611025 | M1T1 5448 |
---|---|---|---|---|---|
M-protein, N terminal (30-valent vaccine) | ✓ | ✓ | ✓ | ||
M-protein, C terminal (J8.0) | ✓ | ✓ | |||
M-protein, C terminal (StreptInCor T-cell epitope) | |||||
M-protein, C terminal (StreptInCor B-cell epitope) | |||||
M-protein, C terminal (StreptInCor common epitope) | ✓ | ||||
adi | MGAS5005_spy1275 | Arginine deaminase | ✓ | ✓ | ✓ |
fbaA | MGAS5005_spy1714 | Fibronectin-binding protein A | |||
fbp54 | AAA57236 | Fibronectin-binding protein 54 | ✓ | ✓ | ✓ |
oppA | M5005_spy0249 | Oligopeptide-binding protein | ✓ | ✓ | ✓ |
GAC | MGAS5005b | Group A carbohydrate | ✓ | ✓ | ✓ |
pulA | SF370_spy1972 | Putative pullulanase | ✓ | ✓ | ✓ |
r28 | AF091393 | Rib-like cell wall protein | |||
scpA | MGAS5005_spy1715 | C5a peptidase | ✓ | ✓ | ✓ |
sfbI | X67947 | Streptococcal fibronectin binding protein I | |||
sfbII-sof | X83303 | Serum opacity factor | ✓ | ||
shr | SPY1530 | Streptococcal hemoprotein receptor | ✓ | ✓ | ✓ |
sib35 | AB254157 | Streptococcal immunoglobulin-binding protein 35 | ✓ | ✓ | ✓ |
slo | M5005_spy0124 | Streptolysin O | ✓ | ✓ | ✓ |
spa | MGAS8232_spyM18_2046 | Streptococcal protective antigen | |||
speA | X03929 | Streptococcal pyrogenic exotoxin A | ✓ | ||
speB | M5005_spy1735 | Cysteine protease | ✓ | ✓ | ✓ |
speC | SF370_spy0711 | Streptococcal pyrogenic exotoxin C | |||
spy0651 | MGAS5005_spy0651 | Cell surface protein | ✓ | ✓ | ✓ |
spy0762 | MGAS5005_spy0762 | Hypothetical membrane associated protein | ✓ | ✓ | ✓ |
spy0942 | MGAS5005_spy0942 | Nucleoside-binding protein | ✓ | ✓ | ✓ |
spyAD | MGAS5005_spy0229 | Adhesin and division protein | ✓ | ✓ | ✓ |
spyCEP | MGAS5005_spy0341 | Interleukin-8 serine protease | ✓ | ✓ | ✓ |
sse | SF370_spy1407 | Serine esterase | ✓ | ✓ | |
tee | MGAS5005_spy0109 | T antigen | ✓ | ✓ | ✓ |
tif | SF370_spy1612 | Trigger factor | ✓ | ✓ | ✓ |
Nucleotide gene sequences derived from completely sequenced genomes or listed GenBank identifiers. Accession numbers for genome sequences include MGAS5005 (CP000017), SF370 (AE004092), and MGAS8232 (AE009949).
GAC operon (∼14.2 kb) refers to MGAS5005 genome coordinates 604873 to 619151.
BLAST analyses at a homology level of 80% for protein antigens and 100% for peptide-derived sequences.