Table 5.
ESKAPE pathogens tested and their corresponding antibiotic resistance profiles as reported by the source provider (BEI Resources or CDC AR Bank) or as determined by antibiotic disc diffusion test (for AMC, IPM, PIP, RA, SXT, and TET) following CLSI breakpoints.
| Species | Strain ID | Alternate ID | Antibiotic resistance profile∗ | Other characteristics |
|---|---|---|---|---|
| Enterococcus faecium | EU-44 | HM-959; Strain 513 | AMC, RIF, SXT, TET, TZP | |
| Staphylococcus aureus | UAMS-1 | Osteomyelitis isolate; MSSA; prototype biofilm isolate | ||
| Klebsiella pneumoniae | CDC-16 | AR-Bank #0016 | AMP, ATMI, FOX, SAMI, TET | Reduced susceptibility, elevated carbapenem MICs |
| Acinetobacter baumannii | CDC-33 | AR-Bank #0033 | CAZ, CIP, CRO, CTX, DOR, FEP, GEN, IPM, LVX, MEM, SAM, SXT, TOB, TZP | Reduced susceptibility, elevated carbapenem MICs |
| Pseudomonas aeruginosa | AH-0071 | PAO1 | ||
| Enterobacter cloacae | CDC-08 | AR-Bank #0008 | AMC, AMP, ATM, CAZ, CFZ, CIP, CRO, CTX, DORI, ETP, FOX, LVX, MEMI, SAM, TET, TZP | Reduced susceptibility, elevated carbapenem MICs |
∗Resistance: AMC, amoxicillin–clavulanic acid; AMP, ampicillin; ATM, aztreonam; CAZ, ceftazidime; CIP, ciprofloxacin; CRO, ceftriaxone; CTX, cefotaxime; DOR, doripenem; ETP, ertapenem; FEP, cefepime; FOX, cefoxitin; GEN, gentamicin; IPM, imipenem; LVX, levofloxacin; MEM, meropenem; RIF, rifampicin; SAM, ampicillin-sublactam; SXT, trimethoprim–sulfamethoxazole; TET, tetracycline; TOB, tobramycin; TZP, piperacillin–tazobactam. Any antibiotics denoted with I indicates resistance.