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. 2019 Feb 7;13:64. doi: 10.3389/fnins.2019.00064

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Copyright © 2019 Khansari and Halliwell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The experimental protocol and timeline for the middle cerebral artery occlusion (MCAO) experiments. Top left is a schematic dorsal view of rat brain and middle cerebral artery and its major branches supplying blood to the temporoparietal cortex. The top right illustrates a ventral view of the intraluminal filament occluding the left internal carotid artery beyond the bifurcation of the left middle cerebral artery to induce MCAO. The lower panel shows the timeline for drug treatment, MCAO, reperfusion and post-MCAO evaluation.