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. 2019 Feb 7;13:64. doi: 10.3389/fnins.2019.00064

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Copyright © 2019 Khansari and Halliwell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mefenamic acid and sodium salicylate are neuroprotective in the rodent transient MCAO model. The histograms show (A) penumbra volume, (B) infarct volume, (C) total ischemic damage (TID) and (D) edema volume in animals treated with either MFA (0.5 or 1 mg/kg), sodium salicylate (1 mg/kg) or vehicle control. Drugs were infused into the left lateral cerebral ventricle by osmotic mini pump for 24 h beginning 1 h prior to MCAO. MFA significantly reduced infarct, edema, and TID; salicylate also reduced infarct and TID but the penumbra volume was not reduced in any of the treatment groups. Values are expressed as mean ± SEM for n = 8 in each group. ^∗p ≤ 0.05; ^∗∗p ≤ 0.01.