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. 2019 Jan 18;14:567–582. doi: 10.1016/j.omtn.2019.01.005

Figure 7.

Figure 7

The Biological Role of MALAT1 in LUAD Cells Was Mediated by miR-200b and E2F3

(A) MTT assays were performed to determine the DTX sensitivity of SPC-A1 cells cotransfected with MALAT1 and miR-200b mimics or sh-E2F3 or sh-ZEB1. (B) MTT assays were performed to determine the DTX sensitivity of SPC-A1/DTX cells cotransfected with shMALAT1 and miR-200b inhibitors or E2F3 or ZEB1. (C) Colony formation assays were used to assess the proliferative ability of SPC-A1/DTX cells cotransfected with shMALAT1 and miR-200b inhibitors or E2F3/ZEB1 overexpression vector. (D) Flow cytometric analysis was used to measure the apoptosis rate of SPC-A1/DTX cells cotransfected with shMALAT1 and miR-200b inhibitors or E2F3/ZEB1 expression vector. (E) Western blot assays were used to measure EMT markers in SPC-A1/DTX cells cotransfected with shMALAT1 and miR-200b inhibitors or E2F3/ZEB1 expression vector. *p < 0.05, **p < 0.01; n.s., no significance.