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Comparative heatmap plots of hierarchical clustering (distance: Pearson, linkage: average, scaled log2 normalized intensity values) comparing different disease states of the microarray dataset, using the R package ComplexHeatmap [22] (distance: Pearson, linkage: average) A. Initial composite signature B. Lasso-optimized, compact composite signature of 7 genes and 5 PET variables. The compact composite signature preserves the discrimination potential of the initial signature.
