Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pediatric low-grade gliomas exhibit frequent genetic alterations that activate the mitogen-activated protein kinase pathway (depicted). Small-molecule inhibitors that have been trialed (or are currently being trialed) in early-phase pediatric clinical trials are shown. The combination of carboplatin and everolimus (shown in red) makes use of distinct mechanisms of action.
