Table 3.

Supratotal resection in high-grade gliomas

First Author	Comparison Made	Surgical Technique	Definition of Supratotal	Volume Assessment	Adjuvant Therapy	Follow-up Time	Outcomes Measured
Eyüpoglu et al (2016)36	DiVA vs Control for supra-complete resection	Dual intraoperative Visualization Approach (DiVA): iMRI with integrated functional navigation and 5-ALA, using an iterative approach.	Beyond both vague and distinct 5-ALA borders and confirmed with iMRI	MRI: T1-weighted MPRAGE 3D, T2, DWI, and BOLD functional with iPlan Cranial Software. Postop assessment at time of operation end.	Radio- chemotherapy with temozolomide.	Up to 44 mo (med: 18.5 mo)	KPS; OS; Neurological deficits
Pessina et al (2017)39	Supratotal vs gross total vs subtotal vs biopsy-only	Maximal removal of the tumor mass according to functional boundaries. Use of intraoperative neuro-navigation and ultrasound. Resection extended in select cases only if no new neurological deficits identified by cortical and subcortical stimulation.	100% of enhanced and FLAIR resection.	MRI: T1, Enhanced, FLAIR; postop <48 h after surgery.	Concurrent and adjuvant chemo- radiotherapy.	4.0–86.5 mo (med: 13.8 mo)	Adjuvant treatment; KPS; PFS; OS; postop morbidity and toxicity.

Abbreviations: BOLD, blood oxygenation level dependent; DWI, diffusion-weighted imaging; MPRAGE, magnetization-prepared rapid acquisition with gradient echo.