Table 3.
Results of amyloid typing based on the proteomic analysis.
| Case | Tissue | Biological replicates | The MS/MS counts of the most abundant amyloid proteins | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ig kappa chain C region | Apolipoprotein E | Ig gamma-1 chain C region | Serum amyloid P-component | Ig gamma-3 chain C region | Apolipoprotein A-IV | Ig kappa chain V-III region SIE | Ig gamma-2 chain C region | Ig kappa chain V-III region VG | Ig alpha-1 chain C region | Apolipoprotein A-I | Ig lambda-2 chain C regions | Gelsolin | Transthyretin | Ig kappa chain V-III region POM | Fibrinogen alpha chain | Proteomic typing | |||
| 1 | Heart | 3 | 51 | 36 | 20 | 19 | 9 | 9 | 8 | 7 | 7 | 5 | 5 | 4 | 4 | 3 | 3 | 2 | A L κ |
| Liver | 3 | 64 | 61 | 15 | 33 | 5 | 11 | 9 | 3 | 9 | 6 | 7 | 6 | 2 | 4 | 3 | 4 | A L κ | |
|
| |||||||||||||||||||
| 2 | Heart | 3 | 56 | 25 | 4 | 10 | 1 | 37 | 2 | 1 | 0 | 1 | 29 | 2 | 7 | 11 | 0 | 11 | A L κ |
| Tongue | 2 | 44 | 17 | 4 | 5 | 1 | 24 | 4 | 0 | 0 | 1 | 31 | 2 | 13 | 14 | 0 | 2 | A L κ | |
|
| |||||||||||||||||||
| 3 | Heart | 3 | 37 | 35 | 2 | 9 | 1 | 53 | 1 | 0 | 0 | 1 | 15 | 2 | 2 | 10 | 0 | 3 | A L κ |
| Liver | 3 | 34 | 62 | 6 | 9 | 3 | 26 | 1 | 0 | 0 | 1 | 4 | 2 | 1 | 9 | 0 | 10 | A L κ | |
|
| |||||||||||||||||||
| 4 | Heart | 3 | 107 | 32 | 13 | 16 | 7 | 45 | 2 | 6 | 0 | 3 | 12 | 4 | 6 | 14 | 1 | 4 | A L κ |
| Liver | 1 | 40 | 33 | 12 | 12 | 5 | 7 | 2 | 5 | 0 | 3 | 8 | 4 | 0 | 6 | 0 | 10 | A L κ | |
|
| |||||||||||||||||||
| 5 | Heart | 3 | 12 | 12 | 1 | 5 | 1 | 12 | 1 | 0 | 0 | 1 | 4 | 1 | 0 | 2 | 4 | 0 | A L κ |
| Small intestine | 3 | 20 | 11 | 2 | 13 | 2 | 38 | 5 | 0 | 1 | 4 | 4 | 2 | 2 | 2 | 5 | 2 | A L κ | |
|
| |||||||||||||||||||
| 6 | Heart | 3 | 7 | 11 | 6 | 5 | 2 | 29 | 1 | 1 | 0 | 4 | 8 | 14 | 2 | 7 | 1 | 4 | A L λ |
| Liver | 2 | 3 | 16 | 6 | 9 | 2 | 32 | 2 | 1 | 1 | 3 | 6 | 12 | 1 | 8 | 0 | 3 | A L λ | |
|
| |||||||||||||||||||
| 7 | Heart | 3 | 6 | 20 | 7 | 20 | 3 | 42 | 2 | 1 | 0 | 4 | 17 | 31 | 6 | 8 | 0 | 10 | A L λ |
| Liver | 2 | 3 | 15 | 6 | 27 | 2 | 31 | 1 | 0 | 0 | 3 | 13 | 17 | 1 | 6 | 0 | 3 | A L λ | |
|
| |||||||||||||||||||
| 8 | Heart | 3 | 5 | 17 | 3 | 15 | 2 | 40 | 1 | 1 | 0 | 5 | 9 | 25 | 1 | 4 | 0 | 6 | A L λ |
| Kidney | 3 | 11 | 23 | 9 | 31 | 4 | 53 | 2 | 5 | 1 | 8 | 8 | 29 | 4 | 10 | 0 | 4 | A L λ | |
|
| |||||||||||||||||||
| 9 | Heart | 3 | 5 | 25 | 5 | 12 | 2 | 10 | 1 | 1 | 0 | 2 | 10 | 30 | 5 | 3 | 0 | 5 | A L λ |
| Liver | 3 | 3 | 44 | 6 | 28 | 2 | 13 | 1 | 1 | 0 | 3 | 13 | 30 | 0 | 4 | 0 | 8 | A L λ | |
|
| |||||||||||||||||||
| 10 | Heart | 3 | 10 | 22 | 6 | 8 | 3 | 31 | 0 | 4 | 0 | 3 | 15 | 26 | 4 | 3 | 0 | 4 | A L λ |
| Kidney | 3 | 13 | 43 | 15 | 13 | 6 | 14 | 2 | 10 | 1 | 7 | 5 | 32 | 5 | 5 | 1 | 4 | A L λ | |
|
| |||||||||||||||||||
| 11 | Heart | 3 | 1 | 14 | 1 | 7 | 0 | 31 | 0 | 1 | 0 | 1 | 1 | 30 | 2 | 1 | 0 | 1 | A L λ |
| Liver | 3 | 1 | 44 | 0 | 10 | 0 | 24 | 0 | 0 | 0 | 2 | 0 | 34 | 0 | 2 | 0 | 9 | A L λ | |
Italic indicates the most abundant amyloid protein in the sample and underline indicates proteins associated with the amyloid formation.