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Adaptive changes occurring in mitochondria in response to hypoxia. Upon prolonged exposure to hypoxia, mitochondria become less abundant, but enriched in sulfide:quinone oxidoreductase (SQR). Consistently, their maximal sulfide-oxidizing activity increases, while overall decreasing in the cell. These changes are proposed to occur to prevent H2S inhibition of cytochrome c oxidase (CcOX) and thus protect cell respiration from H2S poisoning.
