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LRG-1 promotes PDAC cells proliferation and migration via p38/MAPK signaling. a Levels of phosphorylated and total JNK, ERK, p38 and Smad 1/5 were examined by Western blot after 30-min incubation of BxPc-3 and SW1990 cells with LRG-1 (500 ng/ml) for. Wound-healing assay (b) and EdU incorporation assay (c) in cultured PDAC cells after 48 h incubation with SB203580 (0.5 μM) and LRG-1 (500 ng/ml). Data are presented as the mean ± SD, NS = not significant; ***p < 0.001
