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EGFR is critical for LRG-1-mediated malignant behavior of PDAC cells. a EdU incorporation assay, (b) Transwell assay and (c) Wound-healing assay in PDAC cells after 48 h incubation with LRG-1 (500 ng/ml) or LRG-1 + erlotinib (5 μM). d The protein level of MMP-2, MMP-9 and TIMP-1 in PDAC cells after 3-day incubation with LRG-1 (500 ng/ml) or LRG-1 + erlotinib (5 μM). Data are presented as the mean ± SD, *p < 0.05; **p < 0.01; ***p < 0.001
