Table 2.
Detailed information on outcomes extracted from the included studies
| Author (year) | Total N, M, SD of Animals (treatment/control) | ||||||
|---|---|---|---|---|---|---|---|
| Primary outcomes | Secondary outcomes | ||||||
| RVSP | mPAP | mRVP | RV/LV+S | RV/BW | WA | WT | |
| N1, MD1, SD1; N2, MD2, SD2 | N1, MD1, SD1; N2, MD2, SD2 | N1, MD1, SD1; N2, MD2, SD2 | N1, MD1, SD1; N2, MD2, SD2 | N1, MD1, SD1; N2, MD2, SD2 | N1, MD1, SD1; N2, MD2, SD2 | N1, MD1, SD1; N2, MD2, SD2 | |
| Lim et al.(2016) [39] | 5,34.95,1.57;5,39.79,1.57 | 5,0.47,0.03;5,0.52,0.01 | |||||
| Lee et al. (2017) [36] | 6,16,1.63;4,29,3.63 | 6,0.31,0.02;4,0,36,0.0025 | 4,0.91,0.03;4,0.69,0.01 | 6,32.52,0.91;4,42.31,0.9 | |||
| 6,14,0.75;4,49.5,8 | 6,0.69,0.04;4,0.8,0.08 | 4,1.75,0.03;4,0.62,0.01 | 4,34.76,2.71;4,38.22,3.1 | ||||
| 4,14,0.75;4,27,2 | 4,0.32,0.0025;4,0.4,0.01 | 4,0.85,0.02;4,0.69,0.01 | 4,36.16,0.93;4,40.9,2.08 | ||||
| 4,13,1.75;4,44,1.75 | 4,0.62,0.02;4,0.81,0.06 | 4,1.52,0.04;4,0.62,0.01 | |||||
| Guo et al. (2013) [30] | 10,94.69,9.03;10,95.55,12.53 | 10,29.99,6.08;10,30.26,7.83 | 10,0.34,0.06;10,0.37,0.08 | ||||
| Luan et al.(2012) [42] | 20,43.83,2.13;20,56.84,1.54 | 20,26.82,2.13;20,41.37,2.24 | 20,28.34,1.98;20,41.7,6.17 | 20,0.547,0.04;20,0.613,0.07 | 20,20.83,5.49;20,45.21,4.37 | ||
| Baber et al. (2006) [25] | 10,33.48,6;10,44.3,6.35 | 10,0.47,0.03;10,0.6,0.02 | |||||
| Chen et al. (2014) [27] | 7,13.51,1.25;7,29.9,0.71 | 7,0.34,0.03;7,0.56,0.02 | 7,78.62,2.58;7,95.17,10.35 | 7,49.18,3.46;7,73.77,2.77 | |||
| Chen et al. (2016) [26] | 10,28,1.57;10,43,3.18 | 10,0.55,0.08;10,0.78,0.41 | 10,21.21,0.02;10,29.16,0.04 | ||||
| Cheng et al. (2017) [29] | 10,43.76,2.11;10,60.85,1.2 | 10,0.43,0.05;10,0.58,0.02 | 10, 0.42, 0.05;10, 0.51, 0.09 | ||||
| Huang et al.(2016) [31] | 6,47.99,5.53;6,66.7,1.74 | 6, 0.48, 0.04;6, 0.68, 0.09 | |||||
| Chen et al.(2016) [28] | 8, 29.01,1.67; 8,45.81,2.63 | 8,18.76,1.09; 8,30.44,2.23 | |||||
| Jiang et al.(2012) [32] | 43, 28.84, 1.35; 18, 40.2, 3.46 | 43, 0.38, 0.05; 18, 0.58, 0.03 | 43, 36.24, 1.51; 18, 53.47, 3.52 | ||||
| Kang et al. (2015) [33] | 10, 32.72, 1.19; 10, 42.24, 7.52 | 10, 0.5, 0.01; 10, 0.54, 0.07 | 10.32.4, 4; 10, 42, 7.4 | ||||
| Kimet al (2012) [34] | 6, 15.4, 3.8; 6, 38.4, 7.4 | 6, 0.33, 0.06; 6, 0.53, 0.04 | 6, 0.73, 0.02; 6, 0.82, 0.05 | 6, 29.3, 5.2; 6, 38.8, 1.9 | |||
| 6, 14.8, 3.6; 6, 42.3, 13 | 6, 0.64, 0.06; 6, 0.79, 0.04 | 6, 1.47, 0.02; 6, 1.7, 0.09 | 6, 35.7, 5.7; 6, 40.2, 5.4 | ||||
| Kim et al. (2016) [35] | 6, 16.4, 2.1; 6, 34.8, 7.3 | 6, 0.34, 0.27; 6, 0.38, 0.05 | 6, 0.75, 0.02; 6, 0.82, 0.05 | 6, 31.07, 4.71; 6, 38.84, 1.94 | |||
| 6, 13.4, 2.5; 6, 42.2, 13 | 6, 0.48, 0.1; 6, 0.79, 0.04 | 6, 1.3, 0.05; 6, 1.7, 0.07 | 6, 33.64, 3.57; 6, 40.19, 5.38 | ||||
| Liang et al. (2015) [38] | 10, 16.37, 0.94; 10, 26.88, 0.86 | ||||||
| 10, 18.26, 1.41; 8, 32.22, 0.71 | |||||||
| Liu et al. (2015) [40] | 8, 29.86, 2.87; 8, 47.13, 3.31 | 8, 17.53, 1.24; 8, 31.78, 2.16 | |||||
| Luan et al. (2013) [43] | 10, 31.57, 5.54; 10, 44.97, 4.26 | 10, 0.43, 0.05; 10, 0.59, 0.03 | 10, 45.69, 4.21; 10, 56.52, 4.5 | 10, 26.28, 3.95; 10, 36.56, 3.68 | |||
| Luo et al. (2014) [44] | 8, 18.63, 2.15; 8, 24.53, 2.9 | 8, 0.36, 0.04; 17, 0.43, 0.12 | 8, 58.23, 4.08; 8, 68.7, 3.43 | 8, 38.06, 4.15; 8, 46.09, 4.7 | |||
| 8, 23.07, 2.84; 8, 33.18, 3.28 | 8, 0.39, 0.04; 8, 0.49, 0.02 | 8, 62.97, 6.58; 8, 80.48, 6.19 | 8, 40.91, 5.24; 8, 57.26, 4.32 | ||||
| 8, 22.98, 3.24; 8, 36.38, 3.28 | 8, 0.41, 0.01; 8, 0.51, 0.01 | 8, 65.27, 5.45; 8, 84.01, 2.76 | 8, 41.91, 5.16; 8, 64.64, 3.86 | ||||
| Raoul et al. (2007) [45] | 5, 17.65, 2.16; 5, 27.77, 0.94 | 5, 0.3, 0.03; 5, 0.35, 0.02 | |||||
| Rathinasabapathy et al. (2016) [46] | |||||||
| Somanna et al. (2014) [47] | 6, 52.6, 2.79; 6, 56.24, 3.1 | 6, 053, 0.04; 6, 0.51, 0.03 | 6, 0.53, 0.04; 6, 0.51, 0.03 | ||||
| Zhang et al. (2012) [49] | 9, 32.85, 3.44; 9, 59.12, 4.32 | 9, 0.23, 0.01; 9, 0.31, 0.01 | 9, 29.97, 2.21; 9, 53.47, 3.52 | ||||
| Zhang et al. (2012) [50] | 10, 43.83, 2.13; 10, 56.84, 1.54 | 10, 26.82, 3.42; 10, 41.37, 2.24 | 10, 28.34, 1.98; 10, 41.7, 6, 17 | 10, 0.547, 0.041; 10, 0.613, 0.072 | |||
| Umar et al. (2009) [48] | 10, 31, 4; 10, 42, 17 | 10, 0.32, 0.07; 10, 0.47, 0.12 | 10, 0.64, 0.01; 10, 0.93, 0.21 | ||||
| Liu et al. (2011) [41] | 16, 19.83, 2.32; 17, 33.33, 5.36 | 16, 0.36, 0.04; 17, 0.43, 0.12 | |||||
| Takemiya et al. (2009) [15] | 10, 43.73, 3.37; 10, 65.56, 2.3 | ||||||
| Horimoto et al. (2005) [14] | 10, 42.3, 1.1; 10, 58.7, 1.86 | 10, 0.462, 0.029; 10, 0.59, 0.084 | |||||
| Lee et al. (2015) [37] | 8, 23.6, 7.6; 8, 36.5, 3.1 | 8, 1.43, 0.14; 8, 1.47, 0.18 | 8, 1.14, 0.21; 8, 1.01, 0.1 | 8, 34.2, 4; 8, 38.5; 4 | |||
| 8, 21.3, 4.9; 8, 37.2, 6.3 | 8, 2.18, 0.45; 8, 2.89, 0.43 | 8, 1.72, 0.33; 8, 1.62, 0.24 | 8, 33.2, 3.9; 8, 38.8, 6.3 | ||||
| 8, 16.5, 3.6; 8, 52, 19.7 | 8, 1.85, 0.28; 8, 2.88, 0.58 | 8, 1.81, 0.15; 8, 2.67, 0.04 | 8, 37.3, 1.5; 8, 32.3; 2.5 | ||||
N sample number, M mean, SD standard deviation, RVSP right ventricular systolic pressure, mPAP mean pulmonary arterial pressure, mRVP mean right ventricle pressure, RV/LV+S the weight ratio of the right ventricle to the left ventricle plus septum, RV/BW right ventricle to body weight ratio, WA pulmonary arteriole area index, WT wall thickness of pulmonary arteriole