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. 2019 Feb 11;26(1):70–77. doi: 10.1080/10717544.2018.1559258

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — (a) Mean plasma concentration-time curve of dosage of 0.572 mg/kg. The values are expressed as mean ± SD (n = 5); (b) Mean plasma concentration-time curve of dosage of 1.2 mg/kg. The values are expressed as mean ± SD (n = 5). **p < .01 vs free COL, *p < .05 vs free COL; (c) The swelling degree of rats' joint after molding for 12 h; (d) The perimeter change of rats' joint. The values are expressed as mean ± SD (n = 5); (e) The measurement of PGE-2 and TNF-α of rats' joint. The values are expressed as mean ± SD (n = 5). ##p < .01 vs negative control; **p < .01 vs model, *p < .05 vs model.