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. 2019 Feb 11;26(1):78–88. doi: 10.1080/10717544.2018.1556361

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — (A) Representative ERG responses of mice from different animal groups. (B) and (C) Scotopic a- and b-wave amplitudes in the MNU group were significantly smaller than that in the normal control group. The scotopic a- and b-wave amplitudes in the INas administered group was significantly larger than those in the IVen administered group. (D) and (E) The photopic a- and b-wave amplitudes in the MNU group were significantly smaller than those in the normal control group. The photopic a-wave amplitudes in the INas administered group was larger than that in the IVen administered group, however, the difference was not significant. The photopic b-wave amplitudes in the INas administered group was significantly larger than that in the IVen administered group, suggesting the INas delivery of EPO conferred pronounced protection on the ERG function of the MNU administered mice. (F) The mice in the IVen administered group responded better to the raster stimulus than those mice in the MNU group. The visual acuity in the IVen administered group was significantly larger than that in the MNU group. The visual acuity in the INas administered group was significantly larger compared with the IVen administered group. (G) The INas group had a contrast sensitivity significantly larger compared with the IVen administered group (ANOVA analysis followed by Bonferroni's post-hoc analysis was performed, #p < .01, for differences between groups; n = 10).