Table 2.

The Effect of Major Depressive Disorder Polygenic Risk Scores Derived From the NETRIN1 Signaling Pathway and the Whole Genome, Excluding NETRIN1 Pathway Genes, at Polygenic Risk Score Threshold 0.5 on Global Fractional Anisotropy and Three White Matter Tract Categories

	NETRIN1-PRS						Genomic-PRS
	Effect Size, β	SD	t Value	p Value	p Value, FDR Corrected	R2a	Effect Size, β	SD	t Value	p Value	p Value, FDR Corrected	R2a
gFA	−.026	.012	−2.197	.028	.056	.068	−.033	.012	-2.769	.006	.011b	.109
Association Fibers	−.033	.012	−2.762	.006	.023	.107	−.034	.012	-2.836	.005	.011	.113
Thalamic Radiations	−.018	.012	−1.482	.138	.185	.032	−.022	.012	-1.855	.064	.064	.050
Projection Fibers	−.011	.012	−0.904	.366	.366	.012	−.029	.012	-2.415	.016	.021b	.083

FDR, false discovery rate; Genomic-PRS, polygenic risk score derived from the whole genome, excluding NETRIN1 pathway genes; gFA, global fractional anisotropy; NETRIN1-PRS, polygenic risk score derived from the NETRIN1 signaling pathway; PRS, polygenic risk score.

^aR² is the estimate of variance explained by each pathway, in %.

^bStatistically significant p value after false discovery rate correction.