Table 3.

The Effect of NETRIN1-PRS and Genomic-PRS at PRS Threshold 0.5 on Individual White Matter Tracts (Mean Diffusivity Values)

White Matter Tracts	NETRIN1-PRS						Genomic-PRS
	Effect Size, β	SD	t Value	p Value	p Value, FDR Corrected	R2a	Effect Size, β	SD	t Value	p Value	p Value, FDR Corrected	R2a
Association Fibers
Cingulate gyrus part of cingulum	.020	.011	1.877	.061	.130	.040	.035	.011	3.317	.001	.014b	.124
Parahippocampal part of cingulum	−.002	.011	−0.175	.861	.861	.000	.033	.011	3.109	.002	.014b	.107
Inferior fronto-occipital fasciculus	.027	.011	2.461	.014	.047	.075	.031	.011	2.807	.005	.019	.098
Inferior longitudinal fasciculus	.029	.011	2.625	.009	.043b	.086	.025	.011	2.216	.027	.067	.061
Superior longitudinal fasciculus	.034	.011	3.009	.003	.039b	.116	.024	.011	2.133	.033	.071	.058
Uncinate fasciculus	.018	.010	1.698	.090	.168	.085	.029	.010	2.815	.005	.019b	.084
Thalamic Radiations
Anterior thalamic radiation	.025	.011	2.420	.016	.047b	.065	.021	.011	2.028	.043	.080	.046
Posterior thalamic radiations	.025	.011	2.326	.020	.050	.062	.002	.011	0.157	.876	.876	.000
Superior thalamic radiation	.027	.010	2.758	.006	.043b	.074	.018	.010	1.771	.077	.096	.031
Projection Fibers
Acoustic radiation	.004	.010	0.375	.708	.772	.002	.019	.011	1.853	.064	.087	.038
Corticospinal tract	.016	.011	1.399	.162	.221	.025	.022	.011	1.921	.055	.082	.047
Medial lemniscus	.004	.011	0.357	.721	.772	.001	.004	.011	0.396	.692	.741	.002
Forceps major	.018	.012	1.495	.135	.203	−.026	.028	.012	2.362	.018	.055	.019
Forceps minor	.019	.012	1.640	.101	.168	−.063	.023	.012	1.958	.050	.082	−.051
Middle cerebellar peduncle	.013	.012	1.058	.290	.363	.016	.010	.012	0.852	.394	.455	.010

FDR, false discovery rate; PRS, polygenic risk score.

^aR² is the estimate of variance explained by each pathway, in %.

^bStatistically significant p value after false discovery rate correction.