Table 4.

The Effect of NETRIN1-PRS and Genomic-PRS at PRS Threshold 0.5 on Global Mean Diffusivity and Three White Matter Tract Subsets

	NETRIN1-PRS						Genomic-PRS
	Effect Size, β	SD	t Value	p Value	p Value, FDR Corrected	R2a	Effect Size, β	SD	t Value	p Value	p Value, FDR Corrected	R2a
gMD	.028	0.011	2.417	.016	.031	.076	.034	.011	2.924	.003	.007	.111
Association Fibers	.022	0.012	1.897	.058	.077	.048	.042	.012	3.591	.000	.001b	.172
Thalamic Radiations	.030	0.011	2.785	.005	.021b	.089	.013	.011	1.232	.218	.218	.017
Projection Fibers	.021	0.012	1.766	.077	.077	.045	.029	.012	2.380	.017	.023b	.081

FDR, false discovery rate; Genomic-PRS, polygenic risk score derived from the whole genome, excluding NETRIN1 pathway genes; gMD, global mean diffusivity; NETRIN1-PRS, polygenic risk score derived from the NETRIN1 signaling pathway; PRS, polygenic risk score.

^aR² is the estimate of variance explained by each pathway, in %.

^bStatistically significant p values after false discovery rate correction.