Figure 7: Effects of C1-esterase inhibitor (C1–INH) on fibrinolysis in rabbits.

. CHB rabbits were injected with cumulative doses of C1–INH or equal volumes of isotonic saline and blood samples were drawn. Fibrinolysis was induced by addition of tPA and upon extrinsic activation. Lysis index 60 (LI60) was measured using thromboelastography. Bottom and top of the box represent the 25th and 75th percentile, respectively, the band within the box represents the median, the diamond symbol represents the mean, and the low and high ends of the whiskers represent the lowest datum still within 1.5 interquartile range (IQR) of the lower quartile, and the highest datum still within 1.5 IQR of the upper quartile, respectively.