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. 2019 May;14(5):834–840. doi: 10.4103/1673-5374.249231

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Copyright: © Neural Regeneration Research

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Calpeptin administration reduces the number and area of apical dendritic spines, but does not alter pyramidal neurons in the CA1 region in adult animals (60 days).

(A) Regions of NeuN staining (green) and DiI/phalloidin staining (red). (B) Representative images of NeuN staining. Calpeptin injection did not affect pyramidal cell numbers in the CA1 region. (C) DiI staining of the apical spine of the dendrite in the hippocampal CA1. Scale bars: 50 μm in B, 5 μm in C. (D) Numbers of apical dendritic spines were reduced in adult rats following calpeptin treatment. (E) Area of apical dendritic spines was reduced in adult rats following calpeptin treatment. Data are presented as the mean ± SEM (n = 8; independent samples t-test). *P < 0.05, vs. control group.