Table 1.
Plasma alanine aminotransferase (ALT), cholesterol, NEFA and triglyceride levels in NC or HFD-fed mice treated with vehicle, NO2–OA or rosiglitazone. Mice on the NC were treated with vehicle for the last 42 days out the 20 week study. The plasma used was from the terminal blood draw. Data are the mean ± SEM. One-way ANOVA was used and significance was determined as: a, p < 0.05 vs NC; b, p < 0.05 vs HFD mice treated with vehicle.
| Normal Chow (NC) |
High Fat Diet (HFD) |
|||
|---|---|---|---|---|
| Parameters | Vehicle | Vehicle | NO2-OA | Rosi |
| ALT (IU/L) | 121.5 ± 10.9 b | 337.5 ± 68.8 | 157.1 ± 47.0b | 102.0 ± 13.9 b |
| Cholesterol (mg/dL) | 91.2 ± 18.0 | 214.1 ± 10.7a | 217.7 ± 30.0a | 194.4 ± 14.0 a |
| NEFA (mEq/L) | 0.32 ± 0.031 | 0.54 ± 0.034a | 0.44 ± 0.028 | 0.42 ± 0.022 |
| Triglyceride (mg/dL) | 71.4 ± 5.1b | 128.9 ± 15.5 | 65.6 ± 8.8b | 65.5 ± 9.7b |