Table 1.
Cardiopulmonary variables in neonatal sheep. Values are means ± SEM, for pulmonary arterial pressure (PAP), cardiac output (CO) and pulmonary vascular resistance (PVR) recorded in 3, 7 and 12 days old lambs. Groups are control (CN, n = 6) and antenatal melatonin treated (MM, n = 6). Significant differences (P ≤ 0.05): † vs. Day 3.
|
Day 3 |
Day 7 |
Day 12 |
||||
|---|---|---|---|---|---|---|
| CN | MM | CN | MM | CN | MM | |
| mPAP (mmHg) | 36.1 ± 2.7 | 31.6 ± 2.3 | 31.2 ± 3.6 | 30.2 ± 2.0 | 26.4 ± 1.7† | 24.3 ± 2.6† |
| CO (ml min−1 Kg−1) | 383 ± 39 | 407 ± 26 | 377 ± 32 | 362 ± 20 | 314 ± 19† | 317 ± 15† |
| PVR (mmHg ml−1 min−1 Kg−1) | 0.083 ± 0.009 | 0.095 ± 0.009 | 0.084 ± 0.006 | 0.081 ± 0.008 | 0.082 ± 0.008 | 0.072 ± 0.007 |