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. 2019 Feb 11;8:3–8. doi: 10.2147/OV.S189832

Figure 2.

Figure 2

Morbidity and mortality from injection of viruses into the lateral cerebral ventricles.

Notes: vvDD-IL15-Rα and vvDD-RFP were uniformly fatal when virus (2×106 pfus) was injected into the lateral cerebral ventricles. All mice recovered from the same dose of vMyx-IL15Rα-tdTr. (A) Body weight is expressed as a percentage of baseline body weight. (B) Survival curve, vMyx-IL15Rα-tdTr compared to vvDD-IL15-Rα (P<0.0001). n=7 for PBS, n=7 for vvDD-IL15-Rα, n=6 for vMyx-IL15Rα-tdTr, and n=5 for vvDD-RFP.

Abbreviations: RFP, red fluorescent protein; vMyx-IL15Rα-tdTr, myxoma virus expressing IL15-IL15Rα; vvDD, vaccinia virus double deletent; vvDD-IL15-Rα, vaccinia virus expressing IL15-IL15Rα.