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. 2019 Feb 11;8:3–8. doi: 10.2147/OV.S189832

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© 2019 Tang et al. This work is published and licensed by Dove Medical Press Limited

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Differential tropism of two viruses for glioma cells and bone marrow-derived dendritic cells.

Notes: Flow cytometric analysis of expression of virally encoded fluorescent proteins by GL261 cells and bone marrow-derived dendritic cells (BMDCs) treated with vvDD-IL15-Rα (expressing YFP) and vMyx-IL15Rα-tdTr (expressing tdTomato Red). Viruses were at a multiplicity of infection of 5. At 24 hours post infection, cells were harvested, counted for viability assessment, and analyzed by flow cytometry. n=3. Experiment was repeated at 12 hours post infection with similar results. (A) Percentage of GL261 cells expressing virally encoded fluorescent protein. (B) Cytotoxic effect of viruses on GL261 cells. (C) Percentage of BMDC cells expressing virally encoded fluorescent protein. (D) Cytotoxic effect of viruses on BMDC cells. *Significantly different from control cells, P<0.05.

Abbreviations: tdTr, tdTomato Red; vMyx-IL15Rα-tdTr, myxoma virus; vvDD, vaccinia virus double deletent; vvDD-IL15-Rα, vaccinia virus; BMDCs, bone marrow derived dendritic cells; YFP, yellow fluorescent protein.