Fig. 2.

Venn diagrams display shared proteins in the ten most important biological processes (BP) in the species of Spirochaetes targeted in this study. The numbers indicate the mean number of proteins per species involved in each BP. Heat maps included below the Venn diagram of each BP show the Sorensen’s dissimilarity index between the proteins involved in a given process for the different species of bacteria. Rf: Relapsing fever group; LTB: Leptospira spp., Treponema spp., and Brachyspira spp.; Lb: Lyme borreliosis group; FL: free-living species, including the genera Spirochaeta, Sphaerochaeta, and Sediminispirochaeta. The total number of proteins involved in each process is as follows: Carbohydrate metabolism: 263, DNA hydrolysis: 150, DNA repair: 99, Metabolism: 594, Phosphorylation: 358, Redox: 798, Regulation of transcription: 385, Translation: 174, Transmembrane transport: 359, Transport: 711