Table 2.
Systemic and cerebral hemodynamics
| n = 11 | A Baseline |
B Minute ventilation |
C Moderate hyperventilation |
D 50 min of moderate hyperventilation |
E Return to baseline |
|---|---|---|---|---|---|
| HR (beats/min) | 72 (16) | 72 (17) | 71 (17) | 71 (17) | 66 (16) |
| MAP (mmHg) | 92 (10) | 92 (10) | 93 (12) | 90 (10) | 94 (13) |
| ICP (mmHg) | 16 (6) | 8 (5)* | 8 (6)* | 10 (7)* | 14 (6)§¶Ŧ |
| CPP (mmHg) | 77 (9) | 84 (9)* | 85 (10)* | 81 (14) | 80 (11)§¶ |
| PbrO2 (mmHg) | 32 (10) | 33 (9) | 33 (10) | 30 (8)§¶ | 30 (8)§ |
Abbreviations: A Baseline, B Increasing minute ventilation, C Begin moderate hyperventilation with target PaCO2 4–4.7 kPa, D After moderate hyperventilation for 50 min, E Return to baseline, HR Heart rate (beats/min), MAP Mean arterial pressure (mmHg), ICP Intracranial pressure (mmHg), CPP Cerebral perfusion pressure (mmHg), PbrO2 Brain tissue oxygen tension (mmHg)
N = 11 patients; + = 10 patients. Data are expressed as mean (SD)
* p < 0.05 compared with A
§ p < 0.05 compared with B
¶ p < 0.05 compared with C
Ŧ p < 0.05 compared with D