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. 2019 Feb 13;19:32. doi: 10.1186/s12903-019-0720-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Circadian clock hallmarks. A functional circadian clock has to include three characteristics: gene or protein production has to follow an oscillation pattern over approximately 24 h, the circadian rhythm is entrained by an environmental stimulus (zeitgeber [official technical term]) and continues with its oscillation pattern, even after taking away the stimulus