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. 2019 Feb 14;14:4. doi: 10.1186/s13064-019-0128-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — NEP-derived cells failed to populate the IGL at P21. a, b, d and e H&E staining of sagittal sections of anterior cerebellar vermis of P21 Gli2^flox/flox (Control, a), Atoh1-Cre/+; Gli2^flox/flox (Atoh1-Gli2 CKO, b), Nes-FlpoER/+; R26^MASTR/+; Gli2^flox/flox (Nes-Gli2 CKO, d) and Atoh1-Cre/+; Nes-FlpoER/+; R26^MASTR/+; Gli2^flox/flox (Atoh1-Nes-Gli2 CKO, e) mice injected with Tm at P0. Note that inactivation of Gli2 in Nestin-expressing cells inhibits the compensation mechanism in the anterior vermis (black arrowhead in e). c and f FIHC detection of the indicated proteins on mid-sagittal cerebellar sections (lobule I-II) of P21 Atoh1-Cre/+; Gli2^flox/flox; Nes-FlpoER/+; R26^FSF-LacZ/+ (Atoh1-Gli2 CKO; Nes-LacZ, c) and Atoh1-Cre/+; Nes-FlpoER/+; R26^MASTR/+; Gli2^flox/flox (Atoh1-Nes-Gli2 CKO, f) mice injected with Tm at P0. IGL is indicated by the yellow doted line. Scale bars represent 500 μm (a, b, d and e) and 100 μm (c and f)