Table 3.
The most associated epigenome-wide significant signals for both periodontal traits
| bpa | Annotation | Estimateb | P value | FDR | Genec | Reported traits | |
|---|---|---|---|---|---|---|---|
| Gingival bleeding | CHR2: 185463218 | 1st exon; 5′ UTR | − 0.33 | 7.17e−8 | 0.03 | ZNF804A (Zinc Finger Protein 8) |
Bipolar disorder Schizophrenia Memory loss |
| Tooth mobility | CHR7: 2646478 |
Body | 0.38 | 6.85e−8 | 2.5e−4 | IQCE (IQ Motif Containing E) |
Longevity Blood metabolite level |
| CHR8: 11058145 | Body | − 0.49 | 1.53e−8 | 2.8e−3 | XKR6 (XK Related 6) |
Asthma Allergic rhinitis |
aCoordinate based on hg19
bEstimate represents the coefficient generated from the epigenetic linear regression model
cGene name derived from UCSC