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. Author manuscript; available in PMC: 2019 Feb 14.
Published in final edited form as: Clin Pharmacol Ther. 2016 May 20;100(4):371–379. doi: 10.1002/cpt.367

Figure 4.

Figure 4

Dose-dependence of torsadogenicity predictions. Drug distance from decision boundary at concentrations of 0.1,1, 10, and 100 times effective free therapeutic plasma concentration (EFTPC). Positive distance results in a torsadogenic (+Torsades de Pointes (TdP)) prediction, and negative distance results in a nontorsadogenic (-TdP) prediction. Drugs are sorted on the y-axis into known torsadogenic and known nontorsadogenic compounds. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]