Figure 2.

Proposed mechanism of superoxide anion radical neutralization mediated by HP0370, superoxide dismutase and catalase enzymes in H. pylori. In this diagram, we propose that the hydrogen ions generated by biotin carboxylation can be utilized by the superoxide dismutase enzyme to convert superoxide radicals into hydrogen peroxide. This can be further inactivated by AhpC alkyl hydrogen peroxidase into non-deleterious water molecules.