Table 2.
FrxA frameshift and nonsense mutations
| Mutation | Change | Affected codon position | No. of strains |
|
|---|---|---|---|---|
| MR (n = 48) | MS (n = 48) | |||
| Frameshift | −GATTTGCTGCAAAAAAATACGATCC | 13 | 0 | 1 |
| Frameshift | 7A → 6A | 18 | 19 | 11 |
| Frameshift | −G | 20 | 1 | 0 |
| Frameshift | 4G → 3G | 38 | 1 | 0 |
| Frameshift | −TT | 52 | 0 | 1 |
| Frameshift | +TG | 60 | 1 | 0 |
| Frameshift | −C | 70 | 2 | 2 |
| Frameshift | 6G → 7G | 70 | 1 | 1 |
| Frameshift | 6G → 5G | 70 | 2 | 0 |
| Frameshift | GAC → TAAT | 92 | 1 | 0 |
| Frameshift | −G | 106 | 1 | 0 |
| Frameshift | +TATC | 145 | 1 | 0 |
| Frameshift | −G | 168 | 1 | 0 |
| Frameshift | +A | 200 | 0 | 1 |
| Nonsense | CGA → TGA | 13 | 0 | 1 |
| Nonsense | CGA → TGA | 86 | 0 | 1 |
| Total | 31 | 19 | ||
MR, metronidazole-resistant; MS, metronidazole-susceptible.