. 2019 Jan 2;7(1):42–49. doi: 10.1093/gastro/goy048

Table 3.

List of amino-acid substitutions that are significantly associated with metronidazole-resistant H. pylori clinical strains

Cluster^a	Consensus AA residue and position	No. of strains with consensus AA		No. of strains with variant AA		Total variable sites including gaps	Adjusted P-value	Protein description
Cluster^a	Consensus AA residue and position	MR	MS	MR	MS	Total variable sites including gaps	Adjusted P-value	Protein description
522	R16	30	44	13 (H), 5 (C)	4 (H)	72	0.038	Oxygen-insensitive NAD(P)H nitroreductase RdxA (HP0954)
902	D85	38	47	10 (N)	0	33	0.021	Inner-membrane protein RclC (HP0565)
978	V265	35	47	12 (I)	1 (I)	66	0.047	Biotin carboxylase (HP0370)
993	A51	33	47	9 (V), 5 (T)	1 (V)	41	0.006	Putative threonylcarbamoyl–AMP synthase (HP0918)

AA, amino acid; MR, metronidazole-resistant; MS, metronidazole-susceptible.

^aAlignment of each protein cluster is available at the public data repository Figshare (https://figshare.com/), with doi 10.6084/m9.figshare.5271046.