Table 3.

Overall results of 21 cases of AP associated with propofol administration

Author, year	Country	Age, yrs	Sex	Propofol			Latency	Treatment of AP	Follow-up	Outcome	Naranjo scale
				Indication	Duration	Total dose, mg
Leisure et al., 1996 [1]	USA	34	Male	Induction of anesthesia	65 min	200	24 h	Supportive	NR	Recovery	5 (probable)
		43	Male	Induction of anesthesia	NR	NRa	few d	Supportive	NR	Recovery	5 (probable)
		77	Female	Induction of anesthesia	NR	100	1–2 d	Artificial ventilation	Death	Death	4 (possible)
		58	Female	Induction of anesthesia	NR	150	1–2 d	Hemodialysis	Death	Death	4 (possible)
Metkus et al., 1996 [22]	USA	34	Female	Sedation	69 d	NRb	69 d	Drainage of fluid	330 d	Recovery	5 (probable)
Fujii et al., 1998 [23]	Japan	73	Male	Induction of anesthesia	140 min	100	1 d	Supportive	NR	Recovery	5 (probable)
Şentürk and Kerman, 1999 [24]	Turkey	60	Male	Induction of anesthesia	140 min	200	2 d	Supportive	10 d	Recovery	5 (probable)
Bird and Brim, 2000 [25]	UK	34	Male	Induction of anesthesia	15 min	200	1 d	Supportive	7 d	Recovery	5 (probable)
Betrosian et al., 2001[26]	Denmark	35	Male	Induction + maintenance	15 min	140	few h	Hemodialysis	21 d	Recovery	7 (probable)
Jawaid et al., 2002 [20]	USA	21	Female	Induction of anesthesia	138 min	150	1 d	Supportive- antibiotics	21 d	Recovery	7 (probable)
Farina Castro et al., 2002 [27]	Spain	23	Male	Sedation	7 d	103 750	6 d	Supportive	35 d	Recovery	5 (probable)
Manfredi et al., 2004 [21]	Italy	27	Female	Sedation	60 h	600	3 d	Supportive-octreotide	19 d	Recovery	7 (probable)
Gottschling et al., 2005 [28]	Germany	12	Female	Sedation	45 min	235	2 h	Intensive care	NR	Recovery	5 (probable)
Rake et al., 2006 [29]	USA	12	Male	Sedation	<24 h	NR	<24 h	Parenteral nutrition	NR	Recovery	5 (probable)
Coleman et al., 2006 [16]	USA	42	Female	Induction of anesthesia	NR	300	1–2 d	Supportive	> 18 d	Recovery	5 (probable)
Gottesman et al., 2007 [30]	USA	36	Female	Sedation	NR	NR	1 d	Supportive	14 d	Recovery	7 (probable)
Tan et al., 2007 [31]	USA	4	Female	Induction + maintenance	60 min	>45c	10 h	Parenteral nutrition	30 d	Recovery	5 (probable)
Ting and Lee, 2012 [32]	Singapore	14	Female	Sedation	2 d	5043	72 h	Supportive	Death	Deathd	5 (probable)
Muniraj and Aslanian, 2012 [33]	USA	71	Male	Sedation	6 d	8800	5 d	Supportive	17 d	Recovery	7 (probable)
Scholten and Buijs, 2014 [3]	Netherlands	72	Male	Anesthesia maintenance	few h	300	2–3 h	Supportive	365 d	Recovery	7 (probable)
Csomor et al., 2017 [34]	Czech Republic	57	Female	Induction + maintenance	NR	250	15 h	Artificial ventilation, vasopressors, 14 operations	Death	Death	6 (probable)
Total: 21 patients	11 countries	Median35 yrs	10 males 11 females	Sedation: 8 Anesthesia: 13	Median 140 min	Median 200 mg	Intermediate: 14		20 d	Death: 4	Possible: 2 Probable: 19

AP, acute pancreatitis; NR, not reported; min, minute; h, hour; d, day; yrs, years.

^aThe reported dose was 1–1.5 mg/kg without reporting the weight and the duration.

^bThe reported dose was 30–140 µg/kg/min for 69 days without reporting patient weight.

^cThe total dose was 45 mg for induction and not mentioned for maintenance of anesthesia.

^dPatient had viral pneumonia, bacterial tracheitis and septic shock before sedation with propofol and died from bronchopneumonia 12 days after the onset of mild AP onset.