Table 1.

Diagnostic Criteria

Monoclonal gammopathy of undetermined significance Serum monoclonal protein < 3 g/dL Clonal bone marrow plasma cells < 10% Absence of end organ damage attributed to the plasma cell disorder (hypercalcemia, renal failure, anemia, bone lesions)

Smoldering multiple myeloma Serum monoclonal protein (IgG or IgA) > 3 g/dL and/or clonal bone marrow plasma cells 10%-60% Absence of end organ damage attributable to plasma cell disorder

Multiple myeloma Clonal bone marrow plasma cells > 10% or Biopsy proven plasmacytoma and Evidence of end organ damage attributable to underlying plasma cell disorder: Serum calcium > 11.5 mg/dL, and/or Renal insufficiency: serum creatinine > 2 mg/dL, and/or Anemia: hemoglobin < 10 g/dL or > 2 g/dL below lower limit of normal, and/or Bone lesions: lytic lesions, severe osteopenia, or pathological fractures If no end organ damage, then clonal plasma cells > 60%