Figure 6.

Estrogenic Dose Predictions for 266 Chemicals. EAD values (${\log }_{10}$ scale) were predicted from ${\text{ACC}}_{\text{ER}}$ for all 266 potential ER agonists from the ToxCast™ ER pathway model, using the PPK model (∗ symbol) and PPK model with EF (triangle) or ${\mathrm{f}}_{\mathrm{u}}$ (circle) adjustments. PPK, one-compartment population-based PK pharmacokinetic model; PPK_EF, PPK model with EF adjustment applied for ${\text{ACC}}_{\text{ER}}$ in EAD calculation. $\text{PPK}\_{\mathrm{f}}_{\mathrm{u}}$, PPK model with ${\mathrm{f}}_{\mathrm{u}}$ adjustment applied for in vivo ${\mathrm{C}}_{\text{ss}}$ in EAD calculation. Data for this figure are provided in Excel Table S3. ${\text{ACC}}_{\text{ER}}$, pseudo median activity concentration at cutoff from estrogen receptor pathway model; ${\text{CL}}_{\text{int}}$, intrinsic clearance ($\mathrm{L}/\mathrm{h}$); ${\mathrm{C}}_{\text{ss}}$, steady-state plasma concentration; EAD, equivalent administered dose; EF, enrichment factor; ER, estrogen receptor; ${\mathrm{f}}_{\mathrm{u}}$, fraction of chemical unbound to plasma protein.