Fig 2. Distribution along eIF4E and VPg sequences of all mutations found in the 32 randomly chosen variants sequenced in each of the six libraries.

A) eIF4E; B) VPg. NS: non-synonymous; S: synonymous; INDEL: insertion/deletion; STOP: mutation involving the appearance of STOP-codons. For comparative purpose, number of mutations is displayed rather than percentages of mutated sites in the coding sequence, as the two proteins are of comparable length.